P-211 “Survival rates after vitrification of oocytes obtained after luteal phase vs follicular phase ovarian stimulation”

Abstract Study question Do the oocytes retrieved after luteal phase ovarian stimulation (OS) have same survival rate as those follicular (OS)? Summary answer Oocyte vitrification is similar in a OS compared to phase. What known already Oocytes recently captured scientific interest dual gaining popularity. obtained added shorten time pregnancy per intention treat poor responders. Embryos with these show ploidy rates, well clinical outcomes. design, size, duration We analyzed data from randomized, non-inferiority Duo Stim Preimplantation Genetic Testing for aneuploidies (PGT-A) trial performed 2017 2021 women >38 years old. Only cycles at least one oocyte both and were included. rates (n = 154 oocytes) versus 201 within patient. Participants/materials, setting, methods A subtotal of 38 patients included who underwent 2, 3, or 4 accumulate subsequent ICSI PGT-A. After retrieval decumulation, was Kitazato protocol (Kitazato, Japan) Cryotop device, thawing. Main results role chance Mean age selected 39,7 years. In total, 195 cumulus-oocyte complexes vs 245 From this group oocytes, 145/195 mature (78.97%) 201/245 (82.04%), respectively. No statistically significant differences observed whether came 81.16 % (125/154) 87.06% (175/201) (p 0.3312). Our confirm that comparable conventional OS, validating accumulation strategy protocol. Limitations, reasons caution The limited sample size due nature controlled trial. need be replicated larger series validation. Wider implications findings Luteal showed thawing than cycles, opening new venue oncological responders accumulating oocytes. This approach might countries where ethical/legal limitations may limit embryo accumulation. Trial registration number not applicable